Artist whose last names start with "O":
- O'brien, Francis Patrick (1)
- O'Brien, Michael (1)
- O'brien, Richard (29)
- O'Brien, Tim (3)
- O'carolan, Turlough (4)
- O'connor, Mark (2)
- O'Connor, Sinead (8)
- O'day, Anita (6)
- O'Farrill, Chico (1)
- O'Hara, Geoffrey (5)
- O'Neal, Jamie (4)
- O'Neill, John (1)
- O'Reilly, Kim (10)
- O'Sullivan, Gilbert (20)
- O-Town (2)
- O.A.R. (Of a Revolution), (22)
- Oak Ridge Boys, The (25)
- Oakes, David (1)
- Oakland, Ben (1)
- Oasis (394)
- Oates, John (15)
- Obispo, Pascal (6)
- Obst, Michael (2)
- Ocean (13)
- Ocean Colour Scene, (78)
- Ocean, Billy (20)
- Ocean, Frank (15)
- Ochs, Siegfried (1)
- Oden, Annette (1)
- Odetta (1)
- Of Monsters and Men, (30)
- Offenbach, Jacques (28)
- Offishall, Kardinal (2)
- Offspring, The (68)
- Ogawa, Takashi (1)
- Ogdon, John (2)
- Ohio Players, The (8)
- Ohta, Herb (1)
- Oistrakh, David (5)
- OK Go, (26)
- Olcott, Chauncey (20)
- Old Crow Medicine Show, (13)
- Oldfield, Mike (6)
- Olejniczak, Janusz (3)
- Olive (2)
- Oliver, Stephen (2)
- Oliver, Sy (7)
- Olivor, Jane (1)
- Omartian, Michael (6)
- Omi, (18)
- Ondrasik, John (2)
- One Direction, (325)
- OneRepublic (113)
- Ono, Yoko (19)
- Oortmerssen, Jacques van (14)
- Opeth (14)
- Ora, Rita (4)
- Orange Blossom Boys (1)
- Orbison, Roy (148)
- Orlando, Tony (4)
- Orrico, Stacie (5)
- Ortega, Fernando (1)
- Ortiz, Diego (1)
- Ortolani, Riz (1)
- Orton, Beth (2)
- Ortuno, Phillipe Garcia (1)
- Osborne, Jeffrey (6)
- Osbourne, Ozzy (185)
- Osgood, Charles (1)
- Oslin, K.T. (1)
- Osmond, Donny (42)
- Otto, James (1)
- Our Lady Peace (6)
- OutKast, (54)
- Overstreet, Paul (1)
- Overthrow, David (2)
- Owen, Jake (17)
- Owens, Buck (24)
- Owens, Ginny (6)
- Owens, Jimmy (2)
- Owl City, (149)
- Ozark Mountain Daredevils (5)
- Ozawa, Seiji (5)